C 87
CAS No. 332420-90-3
C 87 ( —— )
Catalog No. M26637 CAS No. 332420-90-3
C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 53 | Get Quote |
|
5MG | 87 | Get Quote |
|
10MG | 132 | Get Quote |
|
25MG | 267 | Get Quote |
|
50MG | 493 | Get Quote |
|
100MG | 710 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
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Product NameC 87
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NoteResearch use only, not for human use.
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Brief DescriptionC 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.
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DescriptionC 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.(In Vitro):C 87 reduces the activity of c-Jun N-terminal kinase (JNK) in L929 cells. C 87 prevents the degradation of IκBα in cells treated with TNF-α and potently blocks multiple signaling transduction pathways and downstream target gene activation triggered by TNF-α. C 87 exhibits good solubility and consistent dose-dependent functions in vitro. C 87 completely blocks the TNFα-induced activation of caspase-3 and caspase-8.(In Vivo):In mice, the level of alanine transaminase and aspartate transaminase is consistently reduced. C 87 markedly reduces injuries to the liver and improves animal survival. C 87 injection delays the incidence of death and increases the survival rate by two folds compared with the vehicle control.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number332420-90-3
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Formula Weight502.9
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Molecular FormulaC24H15ClN6O3S
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Purity>98% (HPLC)
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Solubility——
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SMILES[O-][N+](=O)c1cc(N\N=C2\C(=O)N(N=C2c2ccccc2)c2nc(cs2)-c2ccccc2)ccc1Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.J.C, del, R??o, et al. Py–GC/MS study of Eucalyptus globulus wood treated with different fungi[J]. Journal of Analytical and Applied Pyrolysis, 2001.
molnova catalog
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