C 87
CAS No. 332420-90-3
C 87 ( —— )
Catalog No. M26637 CAS No. 332420-90-3
C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 53 | Get Quote |
|
5MG | 87 | Get Quote |
|
10MG | 132 | Get Quote |
|
25MG | 267 | Get Quote |
|
50MG | 493 | Get Quote |
|
100MG | 710 | Get Quote |
|
200MG | Get Quote | Get Quote |
|
500MG | Get Quote | Get Quote |
|
1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameC 87
-
NoteResearch use only, not for human use.
-
Brief DescriptionC 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.
-
DescriptionC 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.(In Vitro):C 87 reduces the activity of c-Jun N-terminal kinase (JNK) in L929 cells. C 87 prevents the degradation of IκBα in cells treated with TNF-α and potently blocks multiple signaling transduction pathways and downstream target gene activation triggered by TNF-α. C 87 exhibits good solubility and consistent dose-dependent functions in vitro. C 87 completely blocks the TNFα-induced activation of caspase-3 and caspase-8.(In Vivo):In mice, the level of alanine transaminase and aspartate transaminase is consistently reduced. C 87 markedly reduces injuries to the liver and improves animal survival. C 87 injection delays the incidence of death and increases the survival rate by two folds compared with the vehicle control.
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
Recptor——
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number332420-90-3
-
Formula Weight502.9
-
Molecular FormulaC24H15ClN6O3S
-
Purity>98% (HPLC)
-
Solubility——
-
SMILES[O-][N+](=O)c1cc(N\N=C2\C(=O)N(N=C2c2ccccc2)c2nc(cs2)-c2ccccc2)ccc1Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.J.C, del, R??o, et al. Py–GC/MS study of Eucalyptus globulus wood treated with different fungi[J]. Journal of Analytical and Applied Pyrolysis, 2001.
molnova catalog
related products
-
Rabdophyllin G
Rabdosin C is an antineoplastic isolated from the leaves of Rabdosia japonic.
-
Dibenzylamine
Dibenzylamine is a part of potent neurogenic agent.
-
1-Stearoyl-sn-glycer...
1-Stearoyl-sn-glycero-3-phosphocholine?is a chemical used in lipid metabolism studies.