C 87

CAS No. 332420-90-3

C 87 ( —— )

Catalog No. M26637 CAS No. 332420-90-3

C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 53 Get Quote
5MG 87 Get Quote
10MG 132 Get Quote
25MG 267 Get Quote
50MG 493 Get Quote
100MG 710 Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    C 87
  • Note
    Research use only, not for human use.
  • Brief Description
    C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.
  • Description
    C 87 is a small-molecule TNF-α inhibitor. C 87 directly binds to TNFα, potently inhibits TNF-α-induced cytotoxicity (IC50 = 8.73 μM), and effectively blocks TNF-α-triggered signaling activities.(In Vitro):C 87 reduces the activity of c-Jun N-terminal kinase (JNK) in L929 cells. C 87 prevents the degradation of IκBα in cells treated with TNF-α and potently blocks multiple signaling transduction pathways and downstream target gene activation triggered by TNF-α. C 87 exhibits good solubility and consistent dose-dependent functions in vitro. C 87 completely blocks the TNFα-induced activation of caspase-3 and caspase-8.(In Vivo):In mice, the level of alanine transaminase and aspartate transaminase is consistently reduced. C 87 markedly reduces injuries to the liver and improves animal survival. C 87 injection delays the incidence of death and increases the survival rate by two folds compared with the vehicle control.
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    332420-90-3
  • Formula Weight
    502.9
  • Molecular Formula
    C24H15ClN6O3S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    [O-][N+](=O)c1cc(N\N=C2\C(=O)N(N=C2c2ccccc2)c2nc(cs2)-c2ccccc2)ccc1Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.J.C, del, R??o, et al. Py–GC/MS study of Eucalyptus globulus wood treated with different fungi[J]. Journal of Analytical and Applied Pyrolysis, 2001.
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